As a designer, Spence has been designing jewelry and custom leather works from a very young age. She was taught how to bead and create handmade leather works by her grandmother, Fabiola Spence. Her inspirations include her Cree heritage, urban culture, vibrant colours and elements. In 2007, Spence released a self-labelled fashion line titled Designs by Rosary which includes Indigenous fashion and footwear, graphic apparel, jewelry and accessories. In 2014, Spence designed limited edition footwear and contributed to original one-of-a-kind footwear as a Storyboot Artist for global shoe company, Manitobah Mukluks. In 2015, Spence joined Indigenous apparel brand Urban Nish as a brand ambassador and design consultant. In 2017, Spence joined international eyewear company, Dreamcatcher Eyewear, as a designer.
From this IKEA project, I developed a further understanding and appreciation for the amount of work that goes into producing a textile collection for a major company I was drawn to the Ts'Kwe Makers Atelier project and working together with Setsuné Fashion Incubator because I believe in and support their vision of empowering Indigenous women through their artistic projects and endeavours, which includes this partnership to create an exclusive product for IKEA. I am thankful for this experience and opportunity to further develop my skills as a designer, seamstress and textile producer, and for the long-lasting friendships and bonds that have also developed from working together with the 6 other artists and textile producers of this project.